Seminar/2018-12-14
From LRDE
Vendredi 14 décembre 2018, 11h-12h, Amphi IP12A
Toward myocardium perfusion from X-ray CT
Clara Jaquet (ESIEE Marne-la-Vallée)
Recent advances in medical image computing have resulted in automated systems that closely assist physicians in patient
therapy. Computational and personalized patient models benefit diagnosis, prognosis and treatment planning, with a
decreased risk for the patient, as well as potentially lower cost. HeartFlow Inc. is a successful example of a company
providing such a service in the cardiovascular context. Based on patient-specific vascular model extracted from X-ray CT
images, they identify functionally significant disease in large coronary arteries. Their combined anatomical and
functional analysis is nonetheless limited by the image resolution. At the downstream scale, a functional exam called
Myocardium Perfusion Imaging (MPI) highlights myocardium regions with blood flow deficit. However, MPI does not
functionally relate perfusion to the upstream coronary disease. The goal of our project is to build the functional
bridge between coronary and myocardium. To this aim we propose an anatomical and functional extrapolation. We produce an
innovative vascular network generation method extending the coronary model down to the microvasculature. In the
resulting vascular model, we compute a functional analysis pipeline to simulate flow from large coronaries to the
myocardium, and to enable comparison with MPI ground-truth data.
After completing a technological university degree in biology at Creteil, Clara Jaquet obtained the diploma of
biomedical engineer from ISBS (Bio-Sciences Institute) in 2015. She worked for one year at HeartFlow Inc, California,
before starting a PhD at ESIEE, Université Paris-Est, within the LIGM laboratory, on a research project jointly with the
same company.